ABSTRACT
Objective: To assess if current practices in bone health monitoring and treatment at a specialist regional cystic fibrosis (CF) centre are in line with current European CF guidelines. Methods: An audit of bone health of all adolescents and adults atWolfson CF centre UK was conducted. Data was gathered between December 2020 and November 2021 from medical records which included timing of last DEXA scan and if it had been within last 5 years, DEXA scan T/Z scores, vitamin D status and bisphosphonate use. Results: 237 individuals were identified, 106 female with a median age of 30 (±15) years. DEXA scans had been conducted in the last 5 years for 70% of the clinic. Of thosewho had a DEXA scan (n = 199), 53% were conducted on time in line with guidelines and 27% were overdue by more than 3 years. Median Z scores were −0.7 (±1.9) at the spine, −0.4 (±1.63) at the neck of femur, −0.6 (±1.5), total femur, and −0.4 (±1.75) total body. CF-related low bone mineral diseasewas present in 0.4–11% of clinic depending on the site of the Z score. 80% of the clinic had had vitamin D levels checked within the last year, with 47% being classed as sufficient (≥75 nmol/L). However, only 3% were classed as deficient with levels below 25 nmol/L. Bisphosphonate treatmentwas indicated in 19% of individuals. However, this had happened in just half of this group. 46% used oral medication, 54% intravenous. Conclusion: The majority of individuals had DEXA scans on time and repeated within 5 years. However, roughly a quarter of individuals were overdue by ≥3 years. Vitamin D levels should be checked at least annually as a minimum and this occurred in the majority of the clinic. There was a very low proportion of vitamin D deficiency but improved monitoring is needed, especially in those with vitamin D insufficiency. Although these results suggest that more robust measures could be in place for bone health monitoring and treatment, the coronavirus pandemic would have had an effect.